{"id":133705,"date":"2026-04-28T19:34:06","date_gmt":"2026-04-28T19:34:06","guid":{"rendered":"https:\/\/alsekeh.com\/?p=133705"},"modified":"2026-04-28T19:34:06","modified_gmt":"2026-04-28T19:34:06","slug":"%d8%af%d9%88%d8%a7%d8%a1-%d9%8a%d8%ae%d9%81%d8%b6-%d8%a7%d9%84%d9%83%d9%88%d9%84%d9%8a%d8%b3%d8%aa%d8%b1%d9%88%d9%84-%d8%a7%d9%84%d8%b6%d8%a7%d8%b1-%d9%88%d9%8a%d8%ad%d8%af-%d9%85%d9%86-%d8%a3%d9%88-2","status":"publish","type":"post","link":"https:\/\/alsekeh.com\/?p=133705","title":{"rendered":"\u062f\u0648\u0627\u0621 \u064a\u062e\u0641\u0636 \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u0636\u0627\u0631 \u0648\u064a\u062d\u062f \u0645\u0646 \u0623\u0648\u0644 \u0646\u0648\u0628\u0629 \u0642\u0644\u0628\u064a\u0629 \u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0643\u0631\u064a"},"content":{"rendered":"

\u0627\u0644\u0633\u0643\u0629 – \u0635\u062d\u0629 \u0648\u062c\u0645\u0627\u0644
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\u0628\u0639\u062f \u0627\u0644\u062a\u062c\u0631\u0628\u0629\u060c \u062f\u0648\u0627\u0621 \u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u0627\u0633\u062a\u0637\u0627\u0639 \u0645\u0646\u0639 \u062d\u062f\u0648\u062b \u0623\u0648\u0644 \u0637\u0627\u0631\u0626 \u0642\u0644\u0628\u064a \u062e\u0637\u064a\u0631 \u0642\u062f \u064a\u0635\u064a\u0628 \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0643\u0631\u064a (\u0634\u062a\u0631\u0633\u062a\u0648\u0643)<\/strong><\/figcaption><\/figure>\n

\u0628\u062f\u064a\u0644 \u0622\u0645\u0646 \u0648\u0641\u0639\u0627\u0644<\/strong><\/h3>\n

\u062d\u0635\u0644 \u062f\u0648\u0627\u0621 \u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u0639\u0644\u0649 \u062a\u0631\u062e\u064a\u0635 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0644\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0639\u0627\u0645 2015 \u0645\u0646 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u0644\u0644\u0633\u064a\u0637\u0631\u0629 \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 (LDL-C) \u0627\u0644\u0645\u0631\u062a\u0641\u0639\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0641\u0631\u0637 \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u0639\u0627\u0626\u0644\u064a \u0623\u0648 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u062a\u0635\u0644\u0628 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646\u060c \u0625\u0630 \u062a\u064f\u0648\u0635\u0641 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0639\u0627\u062f\u0629 \u0645\u0639 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0644\u062e\u0641\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a LDL-C \u0627\u0644\u0645\u0631\u062a\u0641\u0639\u0629 \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u062d\u0645\u064a\u0629 \u063a\u0630\u0627\u0626\u064a\u0629 \u0645\u0646\u0627\u0633\u0628\u0629.<\/strong><\/p>\n

\u0648\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0647\u064a \u0623\u062f\u0648\u064a\u0629 \u0641\u0639\u0627\u0644\u0629 \u0648\u0634\u0627\u0626\u0639\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0644\u062e\u0641\u0636 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u0636\u0627\u0631 \u0648\u0627\u0644\u062f\u0647\u0648\u0646 \u0627\u0644\u062b\u0644\u0627\u062b\u064a\u0629 \u0641\u064a \u0627\u0644\u062f\u0645\u060c \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062b\u0628\u064a\u0637 \u0625\u0646\u0632\u064a\u0645 \u0628\u0627\u0644\u0643\u0628\u062f\u060c \u0645\u0645\u0627 \u064a\u0642\u0644\u0644 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0645\u0646 \u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0646\u0648\u0628\u0627\u062a \u0627\u0644\u0642\u0644\u0628\u064a\u0629 \u0648\u0627\u0644\u0633\u0643\u062a\u0627\u062a \u0627\u0644\u062f\u0645\u0627\u063a\u064a\u0629 \u0648\u062a\u0635\u0644\u0628 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646. \u0648\u062a\u064f\u0639\u062a\u0628\u0631 \u0622\u0645\u0646\u0629 \u0639\u0645\u0648\u0645\u0627\u060c \u0648\u062a\u064f\u0624\u062e\u0630 \u0628\u0627\u0646\u062a\u0638\u0627\u0645\u060c \u0644\u0643\u0646\u0647\u0627 \u0642\u062f \u062a\u0633\u0628\u0628 \u0622\u062b\u0627\u0631\u0627 \u062c\u0627\u0646\u0628\u064a\u0629 \u0645\u062b\u0644 \u0622\u0644\u0627\u0645 \u0627\u0644\u0639\u0636\u0644\u0627\u062a.<\/strong><\/p>\n

\u0648\u064a\u0646\u062a\u0645\u064a \u062f\u0648\u0627\u0621 \u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u0625\u0644\u0649 \u0645\u062b\u0628\u0637\u0627\u062a PCSK9\u060c \u0648\u0647\u064a \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0623\u062c\u0633\u0627\u0645 \u0645\u0636\u0627\u062f\u0629 \u0623\u062d\u0627\u062f\u064a\u0629 \u0627\u0644\u0646\u0633\u064a\u0644\u0629\u060c \u0648\u0643\u0627\u0646 \u0627\u0643\u062a\u0634\u0627\u0641 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a PCSK9 \u0623\u0645\u0631\u0627 \u0645\u0630\u0647\u0644\u0627 \u0639\u0627\u0645 2003\u060c \u0641\u0642\u062f \u0623\u0633\u0647\u0645 \u0644\u0627\u062d\u0642\u0627 \u0641\u064a \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u0641\u0639\u0644\u064a\u0629 \u0627\u0644\u0645\u0645\u0643\u0646\u0629 \u0644\u062a\u062e\u0641\u064a\u0636 \u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u062f\u0645 \u0627\u0644\u0648\u0631\u0627\u062b\u064a.<\/strong><\/p>\n

\u0648\u062a\u062a\u0633\u0628\u0628 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a PCSK9 \u0628\u0625\u062a\u0644\u0627\u0641 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u0636\u0627\u0631 LDL \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0643\u0628\u062f \u0641\u064a\u0631\u062a\u0641\u0639 \u0645\u0633\u062a\u0648\u0649 LDL \u0641\u064a \u0627\u0644\u062f\u0645\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u062d\u0645\u064a \u0645\u062b\u0628\u0637\u0627\u062a PCSK9 \u0627\u0644\u062a\u064a \u064a\u0646\u062a\u0645\u064a \u0625\u0644\u064a\u0647\u0627 \u062f\u0648\u0627\u0621 \u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u0647\u0630\u0647 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0641\u064a\u0632\u062f\u0627\u062f \u0627\u0644\u062a\u0642\u0627\u0637\u0647\u0627 \u0644\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 LDL \u0644\u064a\u0628\u0642\u0649 \u062a\u062d\u062a \u0627\u0644\u0633\u064a\u0637\u0631\u0629.<\/strong><\/p>\n

\u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a<\/strong><\/h3>\n

\u0623\u062b\u0628\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0646\u062c\u0627\u0639\u0629 \u0648\u0641\u0639\u0627\u0644\u064a\u0629 \u062f\u0648\u0627\u0621 \u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u0641\u064a \u062a\u062e\u0641\u064a\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u0636\u0627\u0631 LDL\u060c \u0641\u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629 \u0628\u0645\u062c\u0644\u0629 \u0646\u064a\u0648 \u0625\u0646\u063a\u0644\u0627\u0646\u062f \u062c\u0648\u0631\u0646\u0627\u0644 \u0623\u0648\u0641 \u0645\u064a\u062f\u064a\u0633\u064a\u0646 (New England Journal of Medicine) \u0639\u0627\u0645 2014 \u0627\u0633\u062a\u0637\u0627\u0639 \u062f\u0648\u0627\u0621 \u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u062a\u062e\u0641\u064a\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a LDL \u0628\u0646\u0633\u0628\u0629 60% \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062a\u064a \u0644\u0645 \u062a\u062a\u0644\u0642\u064e\u0651 \u0627\u0644\u062f\u0648\u0627\u0621.<\/strong><\/p>\n

\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0636\u0645\u062a 901 \u0645\u0631\u064a\u0636 \u0648\u0627\u0633\u062a\u0645\u0631\u062a \u0644\u0640 52 \u0623\u0633\u0628\u0648\u0639\u0627\u060c \u0643\u0645\u0627 \u062a\u0648\u0635\u0644 \u0641\u0631\u064a\u0642 \u0628\u062d\u062b\u064a \u0645\u0646 \u0639\u062f\u0629 \u062f\u0648\u0644 \u0625\u0644\u0649 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0630\u0627\u062a\u0647\u0627 \u0628\u0639\u062f\u0645\u0627 \u0627\u062e\u062a\u0628\u0631\u0648\u0627 \u062f\u0648\u0627\u0621 \u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u0639\u0644\u0649 331 \u0645\u0631\u064a\u0636\u0627\u060c \u0648\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0646\u064f\u0634\u0631\u062a \u0641\u064a \u0645\u062c\u0644\u0629 \u0630\u0627 \u0644\u0627\u0646\u0633\u064a\u062a (The Lancet) \u0645\u0648\u0636\u062d\u0629 \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a LDL \u0628\u0646\u0633\u0628\u0629 60%.<\/strong><\/p>\n

\"Old<\/strong>
\u062f\u0648\u0627\u0621 \u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u0645\u0631\u062e\u0635 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0644\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0645\u0646\u0630 \u0639\u0627\u0645 2015 \u0644\u0644\u0633\u064a\u0637\u0631\u0629 \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644\u00a0 (\u0634\u062a\u0631\u0633\u062a\u0648\u0643)<\/strong><\/figcaption><\/figure>\n

\u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u0648\u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a<\/strong><\/h3>\n

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